Kenan Yildiz and Dusan Vlahovic lead the Juventus attack with Adrien Rabiot recovered against Domenico Berardi’s giant-killers Sassuolo.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
You can follow all the build-up and action as it happens from the LIVEBLOG.
Leaders Inter and Juventus both lost to only one team in Serie A this season and it was Sassuolo, so the Bianconeri are out for revenge after their 4-2 defeat in September.
Although Federico Chiesa is fit for the bench and Arkadiusz Milik scored a hat-trick in the midweek 4-0 Coppa Italia win over Frosinone, the front two are Vlahovic and teenage sensation Yildiz.
Weston McKennie and Federico Gatti are suspended, along with long-term bans for Paul Pogba and Nicoló Fagioli.
Moise Kean and Mattia De Sciglio are injured, but Rabiot has shaken off a right thigh issue to start.
Sassuolo beat Fiorentina last week, ending a run of one point from five rounds, and seem to really raise their game against the big clubs.
Gregoire Defrel, Matias Vina, Jeremy Toljan, Agustin Alvarez and Pedro Obiang are not fully fit, but star man Berardi only had cramp against Fiorentina and is ready to start.
Andrea Pinamonti is the centre-forward, with Armand Laurienté in support.
Juventus: Szczesny; Danilo, Bremer, Rugani; Cambiaso, Miretti, Locatelli, Rabiot, Kostic; Vlahovic, Yildiz
Sassuolo: Consigli; Viti, Erlic, Ferrari, Pedersen; Boloca, Matheus Henrique; Berardi, Thorstvedt, Laurienté; Pinamonti
Player statistic
| Dusan Vlahovic (Assist: Fabio Miretti) |
 |
15' | ||
| Dusan Vlahovic | |
37' | ||
| 42' |  |
Martin Erlic |
| 64' | |
Gian Marco Ferrari | ||
| Federico Chiesa (Assist: Manuel Locatelli) |
|
89' |
Match statistic
