Paulo Dybala starts for Roma with Tammy Abraham and Nemanja Matic, returning to face his former teammates amid a Juventus injury crisis that prompts surprise picks.
It kicks off at the Allianz Juventus Stadium at 17.30 UK time (16.30 GMT).
It was only a couple of months ago that Dybala broke down in utterly distraught tears as he said goodbye to the fans in this arena, but he returns for the first time as an opponent wearing the Giallorossi jersey.
La Joya starts with Lorenzo Pellegrini and Abraham, the Italian pushed into a more advanced role to fill in for injured Nicolò Zaniolo, who dislocated his shoulder last week.
Georginio Wijnaldum is out for several months with a fractured fibula, so Matic gets his first midfield start.
Juventus have a serious injury crisis and lost confidence after the dull 0-0 draw away to Sampdoria, so Max Allegri is forced into changes.
Leonardo Bonucci is added to the absentee list along with Angel Di Maria, Paul Pogba, Federico Chiesa and Kaio Jorge, while Wojciech Szczesny returns in goal.
It means Danilo has to move into the centre-back spot, with Fabio Miretti given a surprise midfield start.
Juan Cuadrado, Filip Kostic and Dusan Vlahovic complete the trident attack.
New signing Arkadiusz Milik is on the bench after his loan with option to buy move from Olympique Marseille.
Juventus: Szczesny; De Sciglio, Danilo, Bremer, Alex Sandro; Locatelli, Rabiot, Miretti; Cuadrado, Vlahovic, Kostic
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Matic, Spinazzola; Dybala, Pellegrini; Abraham