Kenan Yildiz partners Dusan Vlahovic and Timothy Weah returns for Juventus, while Roma start Romelu Lukaku and Paulo Dybala, as La Joya faces his former club.
It kicks off at the Allianz Juventus Stadium at 19.45 GMT.
This is a head-to-head for the European places and the revival of an old rivalry, as well as a fascinating battle between Max Allegri and Jose Mourinho.
Federico Chiesa is not quite at 100 per cent, so teenage sensation Yildiz is again chosen to start after scoring on his full debut, this time partnering Vlahovic.
Moise Kean, Alex Sandro and Mattia De Sciglio are injured, with Andrea Cambiaso suspended, plus of course long-term absentees Paul Pogba and Nicolò Fagioli.
Weah returns from his injury lay-off to take the right flank.
Roma are still missing Chris Smalling, Tammy Abraham and Marash Kumbulla, while Renato Sanches is reportedly going to be sent back to PSG six months early from his failed loan spell.
The big news is the return of Dybala from a muscular injury to face his old teammates, partnering Lukaku.
Of course, not only is this Dybala’s visit to his old hunting ground, but Lukaku had also been in negotiations to join Juve over the summer from Chelsea.
Nicola Zalewski has recovered from flu symptoms to start with another former Juve man, Leandro Paredes.
Juventus: Szczesny; Gatti, Bremer, Danilo; Weah, McKennie Locatelli, Rabiot, Kostic; Yildiz, Vlahovic
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Kristensen, Cristante, Paredes, Bove, Zalewski; Dybala, Lukaku
Player statistic
| Adrien Rabiot (Assist: Dusan Vlahovic) |
 |
47' | ||
| 68' |  |
Leandro Paredes | ||
| Manuel Locatelli | |
77' |
Match statistic
