Juventus start Dusan Vlahovic, Federico Chiesa and the returning Danilo, while Napoli try to get their season back on track with Victor Osimhen and Kvicha Kvaratskhelia.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri are still missing Timothy Weah, Mattia De Sciglio, Paul Pogba and Nicolò Fagioli, but have captain Danilo back in the starting XI for the first time in six weeks.
Manuel Locatelli is also fully recovered from a cracked rib, with Chiesa and Vlahovic chosen upfront.
Napoli are the reigning Champions of Italy, but already 11 points adrift of leaders Inter after last week’s humiliating 3-0 home defeat.
Since taking over from sacked Rudi Garcia, Walter Mazzarri has overseen a win away to Atalanta and back-to-back defeats with Real Madrid and Inter.
Mario Rui and Mathias Olivera are still out of action, so Natan is again used as a left-back.
Osimhen might not be at 100 per cent after such a long injury lay-off, but he still starts flanked by Kvaratskhelia and Matteo Politano.
Juve lost both home and away last season, 6-1 on aggregate, and have not beaten Napoli since a 2-1 result here in April 2021.
Juventus: Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Chiesa, Vlahovic
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Natan; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Player statistic
| 45+1' |  |
Khvicha Kvaratskhelia |
| Federico Gatti (Assist: Andrea Cambiaso) |
 |
51' | ||
| Bremer | |
58' | ||
| 63' | |
Juan Jesus | ||
| 86' | |
Leo Östigard | ||
| Manuel Locatelli | |
90+5' | ||
| 90+5' | |
Victor Osimhen |
Match statistic
