Juventus revamp their defence and the wings as they seek revenge against high-flying Monza, but the big news is Paul Pogba and Dusan Vlahovic on the bench.
It kicks off at the Allianz Juventus Stadium in Turin at 14.00 GMT.
The Bianconeri are still reeling from the 15-point penalty inflicted for artificially inflating transfer fees to boost capital gains, which saw them plummet from second to mid-table.
Their rock-solid defence has also seemingly disappeared following a 5-1 defeat to Napoli and 3-3 draw with Atalanta, so Max Allegri brings in Federico Gatti for Alex Sandro and shifts Danilo over to the left of a three-man line.
Federico Chiesa, Juan Cuadrado, Leonardo Bonucci, Daniele Rugani and Kaio Jorge are injured, while Weston McKennie flew out this morning for his Leeds United medical.
Monza famously beat Juventus back on September 18 for their historic first ever Serie A victory, which was also the debut of coach Raffaele Palladino.
He has since steered them up the standings and they reached the midway stage with an impressive tally of 22 points.
Franco Carboni isn’t ready after joining from Inter via Cagliari, with William Bondo and Samuele Vignato injured, plus Giulio Donati not at 100 per cent.
These sides also met in the Coppa Italia only last week, Juve winning 2-1 with a Federico Chiesa curler.
Juventus: Szczesny; Gatti, Bremer, Danilo; De Sciglio, Fagioli, Paredes, Rabiot, Kostic; Di Maria, Kean
Monza: Di Gregorio; Izzo, Pablo Mari, Caldirola; Ciurria, Machin, Rovella, Carlos Augusto; Pessina, Caprari; Mota Carvalho