Juventus launch a new Dusan Vlahovic-Kenan Yildiz partnership against a decimated Milan defence in this head-to-head for second place.
It kicks off at the Allianz Juventus Stadium in Turin at 17.00 UK time (16.00 GMT).
With Inter already winning the Scudetto last week in a Derby della Madonnina face-off, the tension got to the Rossoneri, who saw Theo Hernandez and Davide Calabria both sent off.
They are therefore suspended along with Fikayo Tomori, plus Simon Kjaer, Pierre Kalulu, Mattia Caldara and striker Luka Jovic injured, so Stefano Pioli has to reinvent his defence.
He scraps the experiment of Rafael Leao as a False 9, as Olivier Giroud returns to the starting XI with Christian Pulisic and Ruben Loftus-Cheek.
There was a further problem when Mike Maignan pulled out with an adductor issue in the warm-up, so Marco Sportiello took over in goal.
Juventus lost 2-1 on Tuesday to Lazio, but still scraped through to the Coppa Italia Final 3-2 on aggregate.
Moise Kean is injured, but Federico Chiesa drops to the bench in favour of teenage Turkish sensation Kenan Yildiz as support for Vlahovic.
The Bianconeri have been in dire form recently, winning just three of their last 14 competitive games, in Serie A struggling with back-to-back stalemates against Torino and Cagliari.
Juventus vs. Milan line-ups
Juventus: Szczesny; Gatti, Bremer, Danilo; Weah, Cambiaso, Locatelli, Rabiot, Kostic; Yildiz, Vlahovic
Milan: Sportiello; Musah, Gabbia, Thiaw, Florenzi; Adli, Reijnders; Pulisic, Loftus-Cheek, Leao; Giroud
