Juventus start Paulo Dybala and Giorgio Chiellini on their last games at the Allianz Stadium, but Lazio must fight for Europe without Ciro Immobile.
It kicks off in Turin at 19.45 UK time (18.45 GMT).
The Bianconeri will end the season empty-handed for the first time since 2010-11 under Gigi Delneri, having lost both the Supercoppa and the Coppa Italia to Inter.
They played 120 minutes on Wednesday, eventually falling 4-2 in extra time during the Coppa Italia Final in Rome.
This is above all the farewell match for Dybala, who has not been offered a new contract, and Chiellini, who has not yet decided whether to retire or have a new experience in MLS.
Danilo, Kaio Jorge, Weston McKennie and Federico Chiesa are all injured.
Juve also debut their new jersey for the 2022-23 season, this evening with a special patch for Chiellini.
Lazio are currently in fifth place, but need a win to lock down that Europa League qualification.
Former Juve coach Sarri makes the trip without injured top scorer Immobile, so Felipe Anderson and Jovane Cabral will alternate as a False 9.
Juventus: Perin; Cuadrado, Bonucci, Chiellini, Alex Sandro; Miretti, Locatelli; Bernardeschi, Dybala, Morata; Vlahovic
Lazio: Strakosha; Lazzari, Patric, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Luis Alberto; Felipe Anderson, Cabral, Zaccagni