Juventus rely on Dusan Vlahovic and Federico Chiesa, as Frosinone play Juve-owned Matias Soulé and Walid Cheddira.
It kicks off at the Allianz Juventus Stadium at 11.30 GMT.
The Bianconeri are hanging on to second place despite managing just two points from four rounds, including a home defeat to Udinese and 2-2 draw at Verona.
Gleison Bremer returns from suspension, but Danilo joins Moise Kean, Mattia De Sciglio and Mattia Perin on the treatment table.
Max Allegri tested out a 4-3-3 formation in training, but sticks to 3-5-2 here with Chiesa joining Vlahovic upfront.
There were rumours that Carlos Alcaraz, who arrived in January on loan from Southampton, would start, but instead Fabio Miretti is also on the bench with Weston McKennie moved to a more central role.
Frosinone are struggling too, coming off three consecutive defeats to Milan, Fiorentina and Roma.
Kevin Bonifazi, Riccardo Marchizza, Anthony Oyono, Mateus Lusuardi, Sergio Kalaj, Marvin Cuni and Giuseppe Caso are out of action.
Kaio Jorge, Soulé and Enzo Barrenechea are all on loan from Juventus, but only the Argentine forward starts against their parent club.
Eusebio Di Francesco makes a few surprising adjustments, dropping Kaio Jorge in favour of Walid Cheddira, with Emanuele Valeri in a more advanced role.
Juventus: Szczesny; Gatti, Bremer, Rugani; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Vlahovic, Chiesa
Frosinone: Cerofolini; Lirola, Romagnoli, Okoli, Zortea; Brescianini, Mazzitelli, Harroui; Valeri, Soulè, Cheddira
Player statistic
| Dusan Vlahovic (Assist: Weston McKennie) |
 |
3' | ||
| Bremer |  |
7' | ||
| 14' | |
Walid Cheddira (Assist: Nadir Zortea) | ||
| 27' | |
Marco Brescianini (Assist: Abdou Harroui) | ||
| Dusan Vlahovic (Assist: Weston McKennie) |
|
32' |
| 64' | |
Emanuele Valeri | ||
| 70' | |
Michele Cerofolini | ||
| Manuel Locatelli | |
71' | ||
| Daniele Rugani (Assist: Dusan Vlahovic) |
|
90+5' |
Match statistic
