Juventus revamp with Paulo Dybala, Dusan Vlahovic and Alvaro Morata together and Danilo moved into midfield against Marko Arnautovic’s unpredictable Bologna.
It kicks off at 17.30 UK time (16.30 GMT) at the Allianz Juventus Stadium in Turin.
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The Bianconeri are torn between trying to close the gap on Napoli in third place and keeping an eye over their shoulder at Jose Mourinho’s Roma.
Alvaro Morata and Mattia De Sciglio return from suspension and Max Allegri therefore uses his three strikers together, with Danilo pushed into midfield to protect the defence.
Leonardo Bonucci is still only ready for the bench, with Federico Chiesa, Manuel Locatelli, Arthur Melo, Weston McKennie and Kaio Jorge injured.
Bologna are fresh from a 0-0 draw away to leaders Milan and 2-0 victory over Sampdoria, decided by a Marko Arnautovic brace.
The veteran hitman leads the way again, with support from Riccardo Orsolini and Roberto Soriano, while Scotland international Aaron Hickey is always a danger.
Coach Sinisa Mihajlovic is watching from his hospital room, where he is undergoing treatment for leukaemia.
Juventus: Szczesny; De Sciglio, De Ligt, Chiellini, Pellegrini; Cuadrado, Danilo, Rabiot; Dybala, Vlahovic, Morata
Bologna: Skorupski; Soumaoro, Medel, Theate; Hickey, Svanberg, Schouten, Soriano, Dijks; Arnautovic, Orsolini