Juventus look to Arkadiusz Milik with Federico Chiesa, while Atalanta start Gianluca Scamacca and Teun Koopmeiners in this fascinating European battle.
It kicks off at the Allianz Juventus Stadium in Turin at 17.00 GMT.
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Bianconeri want to keep hold of second place and know a win here would practically lock down a top four finish, but failure would allow Milan to take over after they beat Empoli 1-0.
The last few weeks have not been positive for Juve, who managed just one win in six rounds, two draws and defeats to Inter, Udinese and last week Napoli.
Dusan Vlahovic is suspended, along with long-term absentees Paul Pogba and Nicolò Fagioli, with Adrien Rabiot, Carlos Alcaraz, Mattia De Sciglio and Mattia Perin injured.
It means Milik is chosen to partner Chiesa upfront, with Samuel Iling Junior preferred to Filip Kostic on the left wing.
Weston McKennie returns to bolster the midfield.
Atalanta have hit problems recently too, as they are without a win since February 17, managing only a 1-1 draw with Milan, then defeats to Inter and Bologna.
They were in the Europa League Round of 16 on Wednesday, playing a 1-1 draw with Sporting CP that saw them rattle the frame of the goal three times, so will be hoping for better luck this time around.
Emil Holm is suspended, while squad rotation brings Scamacca and Koopmeiners back into the starting XI, unusually along with Charles De Ketelaere for an attack-minded formation.
Failure to win really would damage Atalanta’s hopes of a top four finish, even after Bologna were beaten by Inter on Saturday.
Three of the last four meetings between these clubs have been draws, with La Dea not beating the Bianconeri since November 2021.
Juventus: Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Miretti, Iling-Junior; Milik, Chiesa
Atalanta: Carnesecchi; Scalvini, Hien, Djimsiti; Zappacosta, Pasalic, Ederson, Ruggeri; Koopmeiners, De Ketelaere; Scamacca
Player statistic
| 35' |  |
Teun Koopmeiners (Assist: Mario Pasalic) |
| Andrea Cambiaso (Assist: Weston McKennie) |
|
66' | ||
| Arkadiusz Milik (Assist: Weston McKennie) |
|
70' | ||
| 75' | |
Teun Koopmeiners (Assist: Berat Djimsiti) | ||
| 90+3' |  |
Hans Hateboer |
Match statistic
