Alessandro Bastoni returns with Lautaro Martinez and Marcus Thuram for Inter, who need a win over Udinese to recapture top spot from Juventus.
It kicks off at San Siro at 19.45 GMT.
As Juventus beat Napoli 1-0 last night with a Federico Gatti header, it means the Nerazzurri are again forced to play catch-up.
They are also preparing for the Champions League showdown with Real Sociedad, which will decide who goes through as top seeds.
Denzel Dumfries, Stefan de Vrij and Benjamin Pavard are all out of action, but Bastoni returns to the starting XI after a month out with a calf strain.
The hosts are wearing special edition kits with the Transformers logo.
Udinese have won only one Serie A match all season, a 1-0 result at San Siro against Milan, although there have been improvements since Gabriele Cioffi took over from Andrea Sottil.
They’ve only lost four this term and are fresh from a 3-3 thriller with Verona including Lorenzo Lucca brace.
Their injury list remains extensive, with Jaka Bijol the latest addition after fracturing a bone in his foot.
He joins Keinan Davis, Gerard Deulofeu, Vivaldo Semedo, Brenner and Enzo Ebosse on the treatment table.
Inter: Sommer; Bisseck, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Udinese: Silvestri; Ferreira, Kabasele, Perez; Ebosele, Samardzic, Walace, Payero, Zemura; Pereyra; Lucca
Player statistic
| 14' |  |
João Ferreira | ||
| Hakan Calhanoglu |  |
37' | ||
| Federico Dimarco (Assist: Hakan Calhanoglu) |
 |
42' | ||
| Marcus Thuram (Assist: Henrikh Mkhitaryan) |
|
44' |
| Lautaro Martínez | |
84' |
Match statistic
