Inter bring back star names like Lautaro Martinez, Marcus Thuram and Federico Dimarco against high-flying Torino, whose strikers are Duvan Zapata and Che Adams.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Atalanta–Genoa on the LIVEBLOG.
The reigning Serie A title holders had a few stumbles this season, drawing away to Genoa and Monza, then losing the Derby della Madonnina against rivals Milan.
However, they got back on track with a hard-fought 3-2 victory away to Udinese, then thrashed Crvena Zvezda 4-0 in the Champions League midweek.
That was despite massive squad rotation, so while Nicolò Barella and Tajon Buchanan are still injured, the likes of Lautaro Martinez, Thuram and Dimarco return.
Torino were top of the table last week, until their 3-2 home defeat to Lazio, their first loss of the campaign, and they go into this round level with Inter on 11 points.
Long-term absentees are Perr Schuurs, Zanos Savva and Emirhan Ilkhan, but goalkeeper Vanja Milinkovic-Savic returns after a knock.
Adams is chosen to partner Duvan Zapata upfront, with Manchester City transfer target Samuele Ricci in midfield.
Coach Paolo Vanoli sits out a touchline ban.
Inter vs. Torino
Inter: Sommer; Bisseck, Acerbi, Bastoni; Darmian, Frattesi, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Torino: Milinkovic-Savic; Walukiewicz, Coco, Maripan; Lazaro, Gineitis, Ricci, Linetty, Pedersen; Adams, Zapata
