Romelu Lukaku and Joaquin Correa lead the attack, as Inter try to get the better of Domenico Berardi’s Sassuolo and leapfrog into at least third place.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
The Nerazzurri are truly on a roll at the moment and barrelling towards an exciting end to the season, as they beat Milan 2-0 in the first leg of the Champions League semi-final on Wednesday and will face Fiorentina in the Coppa Italia Final on May 24.
Only Milan Skriniar remains on the treatment table, but there is a mass squad rotation to prepare for the second leg with the Rossoneri on Tuesday evening, including Samir Handanovic in goal.
A win here would catapult them above Lazio, who were held 2-2 by Lecce last night, into third and temporarily catching Juventus in second place.
Sassuolo are comfortably mid-table now and remain very reliant on the form of their captain Domenico Berardi.
He is aided by the return of Andrea Pinamonti and Nadir Zortea from suspension, while Armand Laurienté is fully fit again.
Inter: Handanovic; D’Ambrosio, De Vrij, Acerbi; Bellanova, Gagliardini, Brozovic, Mkhitaryan, Dimarco; Lukaku, Correa
Sassuolo: Consigli; Toljan, Erlic, Tressoldi, Rogerio; Frattesi, Maxime Lopez, Matheus Henrique; Berardi, Defrel, Laurienté
Player statistic
| 30' |  |
Grégoire Defrel | ||
| Romelu Lukaku (Assist: Danilo D’Ambrosio) |
 |
41' | ||
| 42' | |
Ruan Tressoldi |
| Ruan Tressoldi |  |
55' | ||
| Lautaro Martínez (Assist: Henrikh Mkhitaryan) |
|
58' | ||
| 63' | |
Matheus Henrique (Assist: Domenico Berardi) | ||
| 66' | |
Matheus Henrique | ||
| Stefan de Vrij | |
70' | ||
| 77' | |
Davide Frattesi (Assist: Rogério) | ||
| Marcelo Brozovic | |
84' | ||
| Romelu Lukaku (Assist: Marcelo Brozovic) |
|
89' |
Match statistic
