It kicks off at San Siro at 19.45 UK time (18.45 GMT).
The Nerazzurri have won all five rounds so far, conceding only one goal, and remain the only team still unbeaten in Serie A this season.
Marko Arnautovic was ruled out for at least a couple of months by a thigh strain, joining Juan Cuadrado and Stefano Sensi on the treatment table.
Lautaro Martinez returns to the starting XI with Marcus Thuram and Nicoló Barella, but Davide Frattesi is on the bench against his former club.
Sassuolo are fresh from a 4-2 victory over Juventus, just a week after losing to Frosinone by the same scoreline.
Domenico Berardi remains their shining light and starts with Nedim Bajrami, Armand Laurienté and ex-Inter striker Andrea Pinamonti.
Agustin Alvarez is a long-term absentee, but Andrea Consigli returns in goal.
Inter: Sommer; Darmian, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Sassuolo: Consigli; Toljan, Erlic, Viti, Viña; Boloca, Matheus Henrique; Berardi, Bajrami, Laurentié; Pinamonti
(Assist: Marcus Thuram)
|53'||Nedim Bajrami |
(Assist: Domenico Berardi)
|63'||Domenico Berardi |
(Assist: Jeremy Toljan)