It kicks off at 17.00 UK time (16.00 GMT), you can follow all the build-up and action as it happens from this game and Sassuolo-Milan on the LIVEBLOG.
This is the final round of the season and only two points separate the leaders, but Milan have a superior head-to-head record after taking a win and draw off their rivals.
Therefore, if they finish level at the top, the Rossoneri will still secure the Scudetto.
The only scenario where the Nerazzurri retain their crown of Champions of Italy is if they beat Sampdoria and Milan lose to Sassuolo.
Roberto Gagliardini is the only injury absentee after a knock to the foot during training this week, so Simone Inzaghi had to choose the partner for Lautaro Martinez and plumped for Tucu Correa.
It could be Ivan Perisic’s last game for the club, as a contract renewal is far from certain.
Sampdoria already secured their Serie A safety and celebrated by crushing Fiorentina 4-1 last week.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Correa, Lautaro Martinez
Sampdoria: Audero; Bereszynski, Ferrari, Yoshida, Augello; Candreva, Rincon, Vieira, Thorsby; Sabiri; Caputo