Edin Dzeko and Lautaro Martinez take on Tammy Abraham and Lorenzo Pellegrini as both Inter and Jose Mourinho’s Roma have plenty to play for in this showdown.
It kicks off at San Siro at 17.00 UK time (16.00 GMT), a battle between second and fifth.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Liveblog: Inter-Roma, Venezia-Atalanta, Torino-Spezia, Verona-Sampdoria
This is the first time Mourinho has visited the Stadio Giuseppe Meazza as an opponent after winning the Treble in 2010.
Arturo Vidal is out injured, but after Tuesday’s 3-0 Coppa Italia semi-final victory over Milan, Inter bring back Edin Dzeko and Denzel Dumfries to the starting XI with Lautaro Martinez and Hakan Calhanoglu.
It’s a special match for Dzeko against his former club, but Nicolò Zaniolo cannot do the same, as he is both suspended and injured.
Alessandro Bastoni is not 100 per cent fit, so Federico Dimarco plays in defence.
Bryan Cristante is not fully fit either, with second-choice goalkeeper Daniel Fuzato banned for dissent.
Henrikh Mkhitaryan, Lorenzo Pellegrini and Stephan El Shaarawy support centre-forward Abraham, with Nicola Zalewski now a regular on the left.
Inter are chasing down the Scudetto, Roma closing on Juventus in fourth place and unbeaten in 12 Serie A games.
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Dzeko
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Oliveira, Zalewski; Pellegrini, Mkhitaryan, El Shaarawy; Abraham