Lautaro Martinez and Marcus Thuram try to put Champions League disappointment behind Inter, but Napoli look to Giacomo Raspadori and Kvicha Kvaratskhelia.
It kicks off at San Siro at 19.45 GMT.
This is a handing over of the baton for the Scudetto between the reigning Champions and the runaway leaders, but also mutual consolation after both crashed out of the Champions League midweek.
While Napoli capitulating to Barcelona wasn’t such a shock, it was a surprise for Inter to fumble the first leg lead and go out to Atletico Madrid on penalties.
Marko Arnautovic, Stefano Sensi and Juan Cuadrado are still out of action, but Lautaro Martinez returns to partner Thuram after he was rested for last week’s win away to Bologna.
There were problems for Napoli in training, as Victor Osimhen was struggling with a muscular problem and is only fit for the bench.
Raspadori therefore leads the attack rather than Giovanni Simeone, whose father Diego eliminated Inter from Europe this week.
Kvaratskhelia and Matteo Politano complete the usual attack, with Hamed Junior Traore preferred to Piotr Zielinski, as the Poland international is set to join Inter as a free agent next season.
These teams also met in the Supercoppa Italiana in January, the Nerazzurri squeezing a victory in stoppages to lift the trophy.
Inter: Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Olivera; Anguissa, Lobotka, Traoré; Politano, Raspadori, Kvaratskhelia
Player statistic
| Benjamin Pavard |  |
36' | ||
| Matteo Darmian (Assist: Alessandro Bastoni) |
 |
43' |
| 52' | |
Stanislav Lobotka | ||
| Nicolò Barella | |
54' | ||
| 81' | |
Juan Jesus |
Match statistic
