Serie A returns in 2023 with a Scudetto showdown between Inter and runaway leaders Napoli, as Romelu Lukaku and Edin Dzeko face off against Victor Osimhen and Kvicha Kvaratskhelia.
It kicks off at San Siro at 19.45 GMT.
The Nerazzurri know defeat here could effectively rule them out of the title race, as they went into this round in joint fourth place with Lazio on 30 points, already 11 adrift of Napoli.
There are problems for Simone Inzaghi, who lost Marcelo Brozovic to a muscular injury, while Lautaro Martinez is not risked from the start after winning the World Cup with Argentina only two weeks ago.
Dzeko has been on great form during the winter friendlies and he is partnered with Lukaku, who gets his first start in all competition since August 26.
Brozovic is replaced by Hakan Calhanoglu and Henrikh Mkhitaryan, with Francesco Acerbi favoured over Stefan de Vrij.
Notably, Matteo Darmian is chosen instead of the more attacking Denzel Dumfries.
Napoli ended 2022 a full eight points clear at the top of the table after 11 consecutive Serie A victories.
Luciano Spalletti has a full squad to choose from against his former club, including Matteo Politano, Osimhen and Kvaratskhelia.
Goalkeeper Alex Meret has a slight fever and flu symptoms, but is nonetheless passed fit to start.
Inter: Onana; Skriniar, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Dzeko, Lukaku
Napoli: Meret; Di Lorenzo, Rahmani, Kim Min-jae, Olivera; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia