Inter stick with Lautaro Martinez, Marcus Thuram and Henrikh Mkhitaryan, while Milan trust Olivier Giroud, Rafael Leao and Christian Pulisic, but are forced to change their defence in this top of the table Derby della Madonnina.
It kicks off at a packed out San Siro at 17.00 UK time (16.00 GMT).
After three rounds, these local rivals are the only sides with a perfect Serie A record, so something has to give.
There were five derby meetings last season and Milan lost four in a row between Serie A, the Supercoppa Italiana and Champions League semi-finals, conceding seven goals and scoring none.
Inter make one change from the XI used so far, as Francesco Acerbi has recovered to take over from Stefan de Vrij, making his first appearance of the season.
Despite his heroics scoring twice here for Italy against Ukraine on Tuesday, Davide Frattesi is again benched in favour of Mkhitaryan.
Milan are forced into changes, because Fikayo Tomori is suspended after the red card against Roma and Pierre Kalulu is injured, so Simon Kjaer is the only remaining centre-back.
Giroud limped off during France’s game with the Republic of Ireland after an ankle knock last week, but he has recovered to start with Leao and Pulisic.
Inter: Sommer; Darmian, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Milan: Maignan; Calabria, Kjaer, Thiaw, Theo Hernandez; Loftus-Cheek, Krunic, Reijnders; Pulisic, Giroud, Leao
Player statistic
| Henrikh Mkhitaryan (Assist: Federico Dimarco) |
 |
5' | ||
| 24' |  |
Malick Thiaw | ||
| Marcus Thuram (Assist: Denzel Dumfries) |
|
38' |
| 57' | |
Rafael Leão (Assist: Olivier Giroud) | ||
| 61' | |
Theo Hernández | ||
| Henrikh Mkhitaryan (Assist: Lautaro Martínez) |
|
69' | ||
| Hakan Calhanoglu | |
72' | ||
| Hakan Calhanoglu |  |
79' | ||
| Davide Frattesi (Assist: Henrikh Mkhitaryan) |
|
90+3' | ||
| Davide Frattesi | |
90+4' |
Match statistic
