The Derby d’Italia is also a showdown between the teams who are arguing over who is really in second place, as Inter’s Lautaro Martinez and Romelu Lukaku take on Dusan Vlahovic and Matias Soulé, as Angel Di Maria is not fit to start for Juventus.
It kicks off at San Siro at 19.45 GMT.
Officially, the Nerazzurri are in second place going into this weekend on 50 points and Juve have 38, but if the Bianconeri win their appeal to revoke the 15-point penalty on April 19, then Max Allegri’s men would right now have amassed 53.
Both sides have injury problems after securing their spot in the European quarter-finals and will meet again next month in the Coppa Italia semi-finals.
Alessandro Bastoni, Milan Skriniar and Robin Gosens are out for the hosts, who use Lukaku and Lautaro Martinez upfront with Matteo Darmian going wide.
Moise Kean continues his ban for managing to get sent off within 40 seconds as a substitute against Roma, while Paul Pogba, Alex Sandro, Arkadiusz Milik, Fabio Miretti and Kaio Jorge are injured.
Angel Di Maria and Federico Chiesa are not fit enough to start, so youth team player Soulé gets the nod supporting Vlahovic.
Inter: Onana; Darmian, De Vrij, Acerbi; Dumfries, Barella, Brozovic, Calhanoglu, Dimarco; Lukaku, Lautaro Martinez
Juventus: Szczesny; Gatti, Bremer, Danilo; De Sciglio, Fagioli, Locatelli, Rabiot, Kostic; Soulé, Vlahovic
Player statistic
23' | Filip Kostic (Assist: Adrien Rabiot) | |||
Nicolò Barella | 30' | |||
31' | Federico Gatti |
71' | Adrien Rabiot | |||
88' | Danilo | |||
Danilo D’Ambrosio | 90+7' | |||
Marcelo Brozovic | 90+8' | |||
Danilo D’Ambrosio | 90+7' | |||
90+1' | Leandro Paredes | |||
90+7' | Leandro Paredes |