Inter pick Piotr Zielinski to support Lautaro Martinez and Marcus Thuram, while Juventus go with Dusan Vlahovic, Tim Weah and Francisco Conceicao in the Derby d’Italia.
It kicks off at San Siro at 17.00 GMT.
Check where you can watch on TV here.
This is always a huge fixture in the calendar, even without taking into account they are the main Scudetto contenders along with current leaders Napoli.
The Nerazzurri saw their injury crisis intensify in the Champions League against Young Boys, losing Carlos Augusto for several weeks to a thigh strain.
Hakan Calhanoglu, Francesco Acerbi and Tajon Buchanan are also out of action.
Zielinski gets the nod as playmaker rather than Kristjan Asllani, while Lautaro Martinez and Marcus Thuram return after they were rested midweek.
Juventus lost to VfB Stuttgart in the Champions League, with Douglas Luiz pulling up in the warm-up and joining the absentee list with Teun Koopmeiners, Arek Milik, Nico Gonzalez and Gleison Bremer.
The good news for Thiago Motta is the return of Francisco Conceicao from suspension and Weston McKennie after a muscular issue, while Michele Di Gregorio was banned in Europe.
The Thuram family must wait for the brotherly showdown, because Khephren is on the bench.
However, Tim Weah and Nicolo’ Fagioli are chosen, sending Kenan Yildiz to the sidelines.
Inter vs. Juventus line-ups
Inter: Sommer; Pavard, De Vrij, Bastoni; Dumfries, Barella, Zielinski, Mkhitaryan, Dimarco; M Thuram, Lautaro Martinez
Juventus: Di Gregorio; Cambiaso, Danilo, Kalulu, Cabal; Locatelli, McKennie; Weah, Fagioli, Conceicao; Vlahovic
Season Analytics
Last matches
| 20-10-2024 |
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| 05-10-2024 |
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| 28-09-2024 |
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| 22-09-2024 |
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| 15-09-2024 |
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