It is the Scudetto showdown between the top two, as Lautaro Martinez and Marcus Thuram take on Dusan Vlahovic and Kenan Yildiz, with Inter and Juventus boasting full-strength midfields.
It kicks off at San Siro at 19.45 GMT.
The Nerazzurri are only one point clear at the top of the table, but have a game in hand to be played against Atalanta on February 28.
They were able to retake the leadership last week when 10-man Juve were held by Empoli, so because of that red card, Arkadiusz Milik is suspended with Moise Kean injured.
Adrien Rabiot returns to bolster the midfield, but teenage sensation Yildiz partners Vlahovic, leaving Federico Chiesa on the bench.
Inter have a full-strength squad available, missing only former Juve winger Juan Cuadrado, as Hakan Calhanoglu and Nicoló Barella return from suspension.
Federico Dimarco and Francesco Acerbi were rested last week, but return here for a first-choice XI behind Lautaro Martinez and Thuram.
Inter: Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro Martinez
Juventus: Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Vlahovic, Yildiz
Player statistic
| 18' |  |
Dusan Vlahovic | ||
| 32' | |
Danilo | ||
| Federico Gatti |  |
37' |
| Henrikh Mkhitaryan | |
51' | ||
| Marcus Thuram | |
77' | ||
| 87' | |
Bremer |
Match statistic
