Inter are again forced to do without Marcelo Brozovic and stick with Ivan Perisic, while Fiorentina look to Krzysztof Piatek and Nico Gonzalez.
It kicks off at San Siro at 17.00 GMT, you can follow all the build-up and action as it happens from this game and Cagliari-Milan on the LIVEBLOG.
Serie A Liveblog: Napoli-Udinese, Inter-Fiorentina, Cagliari-Milan
The Nerazzurri need to get back on track after slipping into third place and falling further behind leaders Milan, even if they have a game in hand.
Brozovic was sorely missed in the draw with Genoa and the Croatia international is still out of action with that calf problem, joining Stefan de Vrij on the touchline.
It was believed Robin Gosens would get his first start since joining Inter from Atalanta in January, having now fully recovered from a long-term injury, but they stick with Perisic.
Fiorentina miss Giacomo Bonaventura and Sofyan Amrabat, but Lucas Martinez Quarta is again dropped to the bench.
Nico Gonzalez and Piatek complete the trident attack with Riccardo Saponara.
Inter: Handanovic; D’Ambrosio, Skriniar, Bastoni; Dumfries, Barella, Vidal, Calhanoglu, Perisic; Dzeko, Lautaro Martinez
Fiorentina: Terracciano; Venuti, Milenkovic, Igor, Biraghi; Castrovilli, Torreira, Duncan; Gonzalez, Piatek, Saponara