Inter have Hakan Calhanoglu back after suspension and go with Joaquin Correa alongside Lautaro Martinez as they host unpredictable Empoli.
It kicks off at San Siro at 17.45 UK time (16.45 GMT).
The Nerazzurri can at least temporarily go top of the table awaiting Milan’s trip to Hellas Verona on Sunday and this game is being played early to help prepare for Wednesday’s Coppa Italia Final against Juventus.
Calhanoglu returns from suspension and Samir Handanovic is again fit to start in goal after a back issue ruled him out of the costly defeat to Bologna.
Alessandro Bastoni is still on the treatment table and Nicolò Barella gets no rest after a knee injury scare proved to be just a heavy bruise.
Correa partners Lautaro Martinez, suggesting Edin Dzeko could start against Juve next week.
Empoli have already secured their Serie A safety and came back from 2-0 down to beat Napoli 3-2 a couple of weeks ago.
Petar Stojanovic had a nightmare in the 3-1 defeat to Torino, giving away two penalties for handball.
He was sent off along with Valerio Verre, so both are suspended this evening, with Lorenzo Tonelli, Riccardo Marchizza and Nicolas Haas long-term absentees.
It’s a special game for Inter youth product Andrea Pinamonti, with support from Filippo Bandinelli and Nedim Bajrami.
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Correa
Empoli: Vicario; Fiamozzi, Romagnoli, Luperto, Parisi; Asllani, Stulac, Bandinelli; Bajrami, Zurkowski; Pinamonti