Inter start Marko Arnautovic and Kristjan Asllani with Lautaro Martinez, while Atalanta start Teun Koopmeiners with Charles De Ketelaere.
It kicks off at San Siro at 19.45 GMT.
These Serie A Week 21 fixtures were postponed from January for the Supercoppa Italiana Final Four in Saudi Arabia.
Inter won that tournament and have also won all 10 of their competitive fixtures in 2024, so another here would open up a 12-point lead at the top of the Serie A table.
Marcus Thuram, Hakan Calhanoglu, Francesco Acerbi, Stefano Sensi and Juan Cuadrado are still out of action.
Arnautovic is preferred to Alexis Sanchez as a partner to Capocannoniere Lautaro Martinez, with Asllani and Stefan de Vrij again starting.
Federico Dimarco, Matteo Darmian, Nicolò Barella, Benjamin Pavard and Alessandro Bastoni were rested against Lecce, but return here.
So does Yann Sommer, who missed the Lecce trip with flu symptoms.
Atalanta need a victory to recapture fourth place from Bologna and are on sparkling form with eight wins in their last 11 rounds, fresh from a 1-1 draw in this very stadium against Milan.
Giorgio Scalvini hurt his shoulder during that match, but he is able to start regardless in defence.
Despite suggestions to the contrary, De Ketelaere and Aleksei Miranchuk again start, leaving Ademola Lookman and Gianluca Scamacca on the bench, but Mario Pasalic replaces Marten de Roon.
Atalanta have not beaten Inter since a 4-1 home result in November 2018, managing just five draws and six defeats in all competition.
Their last victory at San Siro was 2-1 in March 2014.
Inter: Sommer; Pavard, De Vrij, Bastoni; Darmian, Barella, Asllani, Mkhitaryan, Dimarco; Arnautovic, Lautaro Martinez
Atalanta: Carnesecchi; Scalvini, Djimsiti, Kolasinac; Hateboer, Ederson, Pasalic, Zappacosta; Miranchuk, Koopmeiners; De Ketelaere
Player statistic
| Matteo Darmian |  |
22' | ||
| Matteo Darmian (Assist: Henrikh Mkhitaryan) |
 |
26' | ||
| Lautaro Martínez (Assist: Benjamin Pavard) |
|
45+1' | ||
| 45' | |
Éderson |
| 53' | |
Berat Djimsiti | ||
| Lautaro Martínez |  |
54' | ||
| Federico Dimarco | |
54' | ||
| 65' | |
Isak Hien | ||
| Davide Frattesi (Assist: Alexis Sánchez) |
|
71' | ||
| 71' | |
Mitchel Bakker | ||
| Alessandro Bastoni | |
76' | ||
| 89' | |
El Bilal Touré | ||
| 90+5' | |
Ademola Lookman |
Match statistic
