Juventus don’t rotate the squad much ahead of the Coppa Italia Final, while Genoa are desperate after sliding four points from safety.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 20.00 UK time (19.00 GMT).
The Bianconeri have already guaranteed a top four finish and Champions League qualification, but Max Allegri doesn’t want to run too many risks of complacency ahead of Wednesday’s Coppa Italia Final against Inter.
Juan Cuadrado and Mattia De Sciglio return from injury, but are replaced by Danilo and Luca Pellegrini, joining long-term absentees Manuel Locatelli, Weston McKennie, Federico Chiesa and Kaio Jorge.
Paulo Dybala and Dusan Vlahovic are not rested, while 18-year-old midfielder Fabio Miretti retains his place after an impressive full debut against Venezia.
Genoa are desperate now, a dramatic 1-0 defeat to Derby della Lanterna rivals Sampdoria sealed by Emil Audero saving Domenico Criscito’s penalty deep into stoppages.
The veteran defender was absolutely distraught and that result left the Grifone four points adrift of safety, as Salernitana leapfrogged them with last night’s 2-1 win over Venezia.
Nikola Maksimovic, Zinho Vanheusden and Lennart Czyborra are on the treatment table.
Genoa: Sirigu; Hefti, Bani, Ostigard, Criscito; Galdames, Badelj; Melegoni, Amiri, Portanova; Destro
Juventus: Szczesny; Cuadrado, Bonucci, Rugani, De Sciglio; Arthur, Miretti, Rabiot; Dybala, Vlahovic, Kean
No wonder Everton are laughing at Juve for taking Kean.
Absolute joke