Inter know a win here could make them Winter Champions, but Lautaro Martinez and Federico Dimarco are still out of action, while giant-killers Genoa have Albert Gudmundsson upfront.
It kicks off at the Stadio Luigi Ferraris, also commonly known as Marassi, at 19.45 GMT.
The Nerazzurri can go seven points clear at the top of the table this evening, meaning that no matter what Juventus do, they cannot catch up before the midway stage of the season.
Lautaro Martinez, Federico Dimarco and Juan Cuadrado are still on the treatment table, with Denzel Dumfries not at 100 per cent either.
Benjamin Pavard is now fully recovered from a dislocated knee, yet Yann Bisseck is again preferred.
It’s Marcus Thuram and Marko Arnautovic upfront again, while Davide Frattesi is suffering from flu symptoms.
Genoa held Juventus to a 1-1 draw here earlier in the month and are coming off a 2-1 win away to Sassuolo.
They also took points off Lazio, Napoli and Roma, so are not to be underestimated.
Both Mateo Retegui and Junior Messias are back in the squad after injury, but only on the bench, while Gudmundsson is a constant danger after nine goals and two assists in 17 competitive games this season.
Kevin Strootman gets the nod in midfield after his injury lay-off.
Genoa: Martinez; De Winter, Bani, Dragusin; Sabelli, Frendrup, Badelj, Strootman, Martin; Gudmundsson, Ekuban
Inter: Sommer; Bisseck, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Carlos Augusto; Arnautovic, Thuram
Player statistic
| 42' |  |
Marko Arnautovic | ||
| Radu Drăgușin (Assist: Albert Gudmundsson) |
|
45+7' |
| Albert Gudmundsson |  |
67' | ||
| Radu Drăgușin | |
69' | ||
| 77' | |
Nicolò Barella | ||
| 85' | |
Henrikh Mkhitaryan |
Match statistic
