Atalanta start Teun Koopmeiners, Charles De Ketelaere and Gianluca Scamacca for this very tricky trip to Mateo Retegui, Albert Gudmundsson and Ruslan Malinovskyi’s Genoa.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.00 GMT.
Both sides are in a splendid period of form, as the Grifone are unbeaten in eight and sit comfortably mid-table, remarkable considering coach Alberto Gilardino took them to promotion from Serie B last season.
Koni De Winter is suspended, with Junior Messias, Ridgeciano Haps and January signing David Ankeye on the treatment table.
The biggest victory of the transfer window was resisting huge offers for Gudmundsson, who again partners Italy international Retegui.
Former Atalanta midfielder Malinovskyi is in midfield with a point to prove.
La Dea are eager to consolidate fourth place after amassing 19 points from the last eight rounds.
Ederson sits out a ban, with Isak Hien and Jose Luis Palomino injured, while Ademola Lookman plays for the Africa Cup of Nations tonight with Nigeria.
However, the big news is the return of Koopmeiners from injury, supporting Scamacca and on-form De Ketelaere.
Genoa: Martinez; Vogliacco, Bani, Vasquez; Sabelli, Malinovskyi, Badelj, Strootman, Frendrup; Retegui, Gudmundsson
Atalanta: Carnesecchi; Scalvini, Djimsiti, Kolasinac; Holm, De Roon, Pasalic, Ruggeri; Koopmeiners; Scamacca, De Ketelaere
Player statistic
22' | Charles De Ketelaere (Assist: Mario Pasalic) | |||
Kevin Strootman | 24' | |||
24' | Charles De Ketelaere | |||
32' | Sead Kolasinac |
Ruslan Malinovskyi (Assist: Milan Badelj) |
51' | |||
Mattia Bani | 54' | |||
55' | Teun Koopmeiners | |||
Aarón Martín | 90+3' | |||
90+2' | Marten de Roon | |||
90+7' | Aleksey Miranchuk | |||
90+10' | Davide Zappacosta | |||
90+13' | El Bilal Touré (Assist: Aleksey Miranchuk) |