Juventus give 18-year-old sensation Kenan Yildiz his first start with Arek Milik, as Frosinone starlets Matias Soule, Kaio Jorge and Enzo Barrenechea face their parent club.
It kicks off at the Stadio Stirpe at 11.30 GMT.
The Bianconeri fell four points adrift of leaders Inter after their 1-1 draw with Genoa and need to get back on track, but find themselves dealing with a striker shortage.
Federico Chiesa, Moise Kean and Mattia De Sciglio are out, while Dusan Vlahovic is not 100 per cent fit either.
Max Allegri decides to gamble on 18-year-old Turkey international Kenan Yildiz, who has impressed so much for the NextGen team and attracted interest from Liverpool.
Adrien Rabiot returns from injury, though Paul Pogba and Nicolò Fagioli are of course still suspended for off the field issues.
Frosinone are fresh from a shock 4-0 Coppa Italia victory away to Napoli on Tuesday evening and are fairly comfortably mid-table in Serie A too.
Caleb Okoli is suspended, while Riccardo Marchizza, Sergio Kalaj Reinier, Arjon Ibrahimovic, Luca Mazzitelli and Michael Oyono are injured.
It is unusual to see so many players face their parent club, but Soule, Barrenechea and Kaio Jorge are all on loan from Juventus.
Frosinone: Turati; Monterisi, Romagnoli, Lusuardi; Lirola, Gelli, Barrenechea, Brescianini, Garritano; Soulé, Kaio Jorge
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Cambiaso, McKennie, Locatelli, Rabiot, Kostic; Yildiz, Milik
Player statistic
| 12' |  |
Kenan Yıldız (Assist: Filip Kostic) | ||
| 20' |  |
Andrea Cambiaso | ||
| 43' | |
Weston McKennie |
| Jaime Báez (Assist: Ilario Monterisi) |
|
51' | ||
| 81' | |
Dusan Vlahovic (Assist: Weston McKennie) |
Match statistic
