Charles De Ketelaere scored on his Atalanta debut, but he is again on the bench with Gianluca Scamacca for this trip to Frosinone, who start ex-Juventus man Enzo Barrenechea.
It kicks off at the Stadio Stirpe at 17.30 UK time (16.30 GMT).
La Dea began their season with a 2-0 victory away to Sassuolo and De Ketelaere did what he had failed to in an entire season at Milan, score a goal.
His header broke the deadlock late on, with Nadir Zortea adding another in stoppages, but the Belgian and fellow summer signing Scamacca are again on the bench.
El Bilal Toure is out for some time after surgery on a torn tendon in his thigh, joining Hans Hateboer and Jose Luis Palomino on the treatment table.
Frosinone had taken the lead against champions Napoli, only to eventually capitulate 3-1.
Goalkeeper Stefano Turati is suspended after he was caught on camera using a blasphemous phrase, which in the Italian language is the worst form of swearing.
Michele Cerofolini therefore starts in goal, with Walid Cheddira and Barrenechea thrown straight into the XI after their arrival from Napoli and Juventus on loan.
Frosinone: Cerofolini; Oyono, Monterisi, Romagnoli, Marchizza; Gelli, Barrenechea, Mazzitelli; Baez, Cheddira, Harroui
Atalanta: Musso; Djimsiti, Scalvini, Kolasinac; Zappacosta, De Roon, Koopmeiners, Ruggeri; Ederson; Lookman, Duvan Zapata
Player statistic
| Abdou Harroui (Assist: Riccardo Marchizza) |
 |
5' | ||
| Ilario Monterisi (Assist: Simone Romagnoli) |
|
24' | ||
| Enzo Barrenechea |  |
29' | ||
| 40' | |
Ademola Lookman | ||
| 45+4' | |
Marten de Roon |
| 56' | |
Duván Zapata |
Match statistic
