Roma and Fiorentina face off for European places with plenty of attacking talent from Arthur Cabral, Tammy Abraham, Jonathan Ikone and Lorenzo Pellegrini.
It kicks off at the Stadio Franchi at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Viola are three points behind the Giallorossi going into this game, while Rome need a win to stay level with Lazio in fifth.
Fresh from the Conference League semi-final with Leicester on Thursday evening, Jose Mourinho is still missing injured Henrikh Mkhitaryan.
He again keeps squad rotation to an absolute minimum, but makes some adjustments with a packed midfield, moving Lorenzo Pellegrini to the Nicolò Zaniolo role supporting Abraham.
Fiorentina choose Arthur Cabral to lead the trident attack with Nico Gonzalez and Ikone, while Lucas Torreira is not 100 per cent fit.
Gaetano Castrovilli is out for the rest of the season.
When these sides met in the opening weekend, Roma emerged 3-1 winners at the Stadio Olimpico after Viola goalkeeper Bartlomiej Dragowski was sent off just 17 minutes in.
Nicolò Zaniolo also saw red for two bookable offences in the fiery match.
Fiorentina: Terracciano; Venuti, Milenkovic, Igor, Biraghi; Bonaventura, Amrabat, Duncan; Nico Gonzalez, Cabral, Ikone
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Sergio Oliveira, Cristante, Zalewski; Pellegrini, Abraham