Paulo Dybala returns to the starting XI with Artem Dovbyk as Roma pay a difficult visit to Fiorentina, including David De Gea and their former midfielder Edoardo Bove.
It kicks off at the Stadio Artemio Franchi at 19.45 GMT.
Both sides were involved in Europe on Thursday, but squad rotation has to be kept to a minimum due to the number of players out injured.
Fiorentina are still missing Albert Gudmundsson, Rolando Mandragora and Marin Pongracic, with Moise Kean back in the starting XI after their 4-2 win away to St. Gallen.
It is a very special game for Bove, who was born and raised in the Roma youth academy.
Roma are missing Stephan El Shaarawy and Alexis Saelemaekers, while Matias Soulé is still struggling with flu symptoms.
Gianluca Mancini has recovered from that virus and is ready to play, but above all Dybala and Lorenzo Pellegrini return to support Dovbyk after the hard-fought 1-0 win over Dynamo Kyiv.
Fiorentina vs. Roma line-ups
Fiorentina: De Gea; Dodo, Comuzzo, Ranieri, Gosens; Adli, Cataldi; Colpani, Beltran, Bove; Kean
Roma: Svilar; Mancini, Ndicka, Hermoso; Celik, Pisilli, Cristante, Angelino; Dybala, Pellegrini; Dovbyk
Player statistic
| Moise Kean (Assist: Lucas Beltrán) |
 |
9' | ||
| Lucas Beltrán |  |
17' | ||
| 39' | |
Manu Koné (Assist: Mario Hermoso) | ||
| Moise Kean (Assist: Edoardo Bove) |
|
40' | ||
| 42' |  |
Gianluca Mancini |
