Victor Osimhen is injured, so Giovanni Simeone and Kvicha Kvaratskhelia start for Napoli in the showdown for Europe with M’Bala Nzola and Nico Gonzalez’s Fiorentina.
It kicks off at the Stadio Artemio Franchi at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
These sides are separated by just two points, but the Viola also have a game in hand against Atalanta to be played on June 2.
They are therefore the favourites to take eighth place and qualify for the Conference League, though that might be irrelevant if they beat Olympiacos on May 29 in the Conference League Final and therefore qualify directly for the Europa League.
Riccardo Sottil is the only remaining injury absentee, as Giacomo Bonaventura returns, with Nico Gonzalez, Lucas Beltran and Kouame fanning out behind Nzola rather than Andrea Belotti.
Napoli are missing Osimhen, Mario Rui, Piotr Zielinski and Pierluigi Gollini, but Kvaratskhelia is fully recovered and starts with Simeone and Matteo Politano.
Captain Giovanni Di Lorenzo had a stomach bug last night, so Pasquale Mazzocchi takes his place.
These sides met in the Supercoppa Italiana semi-final in January, Napoli winning 3-0 and Jonathan Ikone missing a penalty.
Fiorentina vs. Napoli line-ups
Fiorentina: Terracciano; Dodo, Milenkovic, Martinez Quarta, Biraghi; Arthur, Bonaventura; Nico Gonzalez, Beltran, Kouame; Nzola
Napoli: Meret; Mazzocchi, Rrahmani, Ostigard, Olivera; Anguissa, Lobotka, Cajuste; Politano, Simeone, Kvaratskhelia
Player statistic
8' | Amir Rrahmani (Assist: Matteo Politano) | |||
Cristiano Biraghi | 40' | |||
41' | Khvicha Kvaratskhelia | |||
M’Bala Nzola | 42' |
57' | Khvicha Kvaratskhelia | |||
70' | Jens Cajuste | |||
Rolando Mandragora | 84' |