Alvaro Morata returns for Milan with Christian Pulisic and Rafael Leao, as Fiorentina hope David De Gea, Albert Gudmundsson and Moise Kean can secure a victory.
It kicks off at the Stadio Artemio Franchi at 19.45 UK time (18.45 GMT).
The Rossoneri are definitely back on track domestically after three consecutive victories, including the Derby della Madonnina against rivals Inter.
Their Champions League form isn’t quite so good, losing to Liverpool and Bayer Leverkusen, but the performances have certainly improved.
Morata returns to the starting XI after muscular issues, but Ruben Loftus-Cheek joins Luka Jovic, Davide Calabria, Ismael Bennacer, Marco Sportiello and Alessandro Florenzi on the absentee list.
Theo Hernandez receives a gift on his birthday, as he gets the captain’s armband.
Fiorentina were also in action on Thursday, pushing past The New Saints in their opening Conference League fixture.
Rolando Mandragora damaged the meniscus in his knee during that game and is out along with Marin Pongracic.
The Viola won only two games since Raffaele Palladino took over, drawing six and losing one to Atalanta.
Big summer investment Gudmundsson starts in a 4-2-3-1 formation behind Kean, while veteran goalkeeper De Gea takes the gloves.
Yacine Adli faces his parent club in midfield, with Robin Gosens seemingly at left-back rather than captain Cristiano Biraghi.
Fiorentina vs. Milan line-ups
Fiorentina: De Gea; Dodo, Comuzzo, Ranieri, Gosens; Cataldi, Adli; Colpani, Gudmundsson, Bove; Kean
Milan: Maignan; Emerson Royal, Tomori, Gabbia, Theo Hernandez; Fofana, Reijnders; Pulisic, Morata, Leao; Abraham
