Fiorentina try to get back on track with Nico Gonzalez and M’Bala Nzola, but Charles De Ketelaere is getting into gear with Atalanta and Gianluca Scamacca not fully fit.
It kicks off at the Stadio Franchi at 17.00 UK time (16.00 GMT).
The Viola went into the break for international duty off a 4-0 thrashing at the hands of Inter that dented their confidence.
Maxime Lopez is still suspended for a red card he earned with Sassuolo before the transfer, while Yerry Mina has joined Jonathan Ikone and Gaetano Castrovilli on the treatment table.
Nzola is preferred to Lucas Beltran in the centre-forward role, with support from Nico Gonzalez, Giacomo Bonaventura and Josip Brekalo.
Atalanta remain unpredictable, as they swept Sassuolo and Monza aside only to suffer a defeat away to newly-promoted Frosinone.
Scamacca and De Ketelaere are rediscovering their form already after tough seasons at their old clubs, but the Italian is struggling with a tendon issue.
Aleksei Miranchuk joins El-Bilal Toure on the absentee list, but Rafael Toloi returns.
Fiorentina: Terracciano; Dodo, Milenkovic, Martinez-Quarta, Parisi; Mandragora, Duncan; Nico Gonzalez, Bonaventura, Brekalo; Nzola
Atalanta: Carnesecchi; Toloi, Scalvini, Kolasinac; Zappacosta, De Roon, Ederson, Ruggeri; Koopmeiners; De Ketelaere, Lookman
Player statistic
| 20' |  |
Teun Koopmeiners (Assist: Marten de Roon) | ||
| 34' |  |
Marten de Roon | ||
| Giacomo Bonaventura (Assist: Nicólas González) |
|
35' | ||
| Lucas Martínez Quarta (Assist: Alfred Duncan) |
|
45' |
| 53' | |
Ademola Lookman (Assist: Marten de Roon) | ||
| 65' | |
Nadir Zortea | ||
| Christian Kouamé | |
76' | ||
| Fabiano Parisi | |
87' |
Match statistic
