Juventus give Douglas Luiz, Teun Koopmeiners, Nico Gonzalez and Pierre Kalulu their first starts for the tricky trip to Empoli, who have caused a few upsets this season.
It kicks off at the Stadio Castellani at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from this game, Como-Bologna and Milan–Venezia on the LIVEBLOG.
The Bianconeri saw their perfect start to the season ended by a 0-0 draw with Roma, but remain unbeaten and without conceding a single goal.
Francisco Conceicao has joined Arkadiusz Milik on the treatment table, but new signings Douglas Luiz and Koopmeiners get their first starts in midfield.
Nico Gonzalez and Kenan Yildiz also fan out behind striker Dusan Vlahovic, while Andrea Cambiaso is moved to full-back with debutant Kalulu.
Empoli are also unbeaten so far this term, holding Monza and Bologna to draws, while earning a shock 2-1 win away to Roma.
Szymon Zurkowski, Luca Belardinelli, Samuele Perisan, Jacopo Fazzini and Tyronne Ebuehi are all injured.
Mattia De Sciglio is not yet ready to face his former club, but Sebastiano Esposito supports Lorenzo Colombo.
Empoli vs. Juventus line-ups
Empoli: Vasquez; Goglichidze, Ismajli, Viti; Gyasi, Grassi, Henderson, Maleh, Pezzella; Esposito, Colombo
Juventus: Perin; Kalulu, Bremer, Gatti, Cambiaso; Locatelli, Douglas Luiz; Nico Gonzalez, Koopmeiners, Yildiz; Vlahovic
Match statistic
