Atalanta try to get back on track after their first defeat of the season, starting Ademola Lookman and Rasmus Hojlund in a young strike force against Empoli.
It kicks off at the Stadio Castellani at 11.30 GMT.
La Dea were unbeaten and battling for top spot until their 2-0 home defeat to Lazio, a game that also saw Luis Muriel sent off and he is therefore suspended.
Marten de Roon and Davide Zappacosta are injured, with Duvan Zapata not 100 per cent fit, so young striker Hojlund – nicknamed the new Erling Haaland – leads the way with on-form Lookman.
The good news is the return of Juan Musso and Rafael Toloi.
Empoli are coming off a bruising 4-0 loss to Juventus, but are also the only side to have so far beaten Raffaele Palladino’s Monza.
Alberto Grassi and Lorenzo Tonelli are still on the treatment table, but coach Paolo Zanetti completely transforms his line-up with numerous changes.
Empoli: Vicario; Ebuehi, De Winter, Luperto, Cacace; Henderson, Marin, Bandinelli; Bajrami; Pjaca, Destro
Atalanta: Musso; Toloi, Demiral, Scalvini; Hateboer, Pasalic, Koopmeiners, Maehle; Ederson; Lookman, Hojlund