Napoli look unstoppable at the moment and Giacomo Raspadori leads the way against Cremonese looking for an eighth consecutive victory in all competitions.
It kicks off at the Stadio Giovanni Zini at 17.00 UK time (16.00 GMT).
The Partenopei are coming off an astonishing 6-1 Champions League triumph away to Ajax and went into the weekend as joint Serie A leaders with Atalanta.
Victor Osimhen is still out injured, but has not been missed, because they’ve won seven on the bounce in all competitions.
There is hardly any squad rotation, Tanguy Ndombele in for not fully fit Piotr Zielinski, and Raspadori is again preferred to Giovanni Simeone upfront.
Cremonese were promoted from Serie B over the summer and are still looking for their first win of the season after three draws and five defeats.
The stalemates were against Sassuolo, Atalanta and Lecce.
Jack Hendry is out and Vlad Chiriches carrying a knock, but the changes are upfront with Felix Afena-Gyan, Luca Zanimacchia and Giacomo Quagliata supporting Cyriel Dessers.
Cremonese: Radu; Sernicola, Bianchetti, Lochoshvili, Valeri; Meité, Ascacibar; Zanimacchia, Afena-Gyan, Quagliata; Dessers
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Ndombele; Politano, Raspadori, Kvaratskhelia