Inter are forced into changes against a revitalised Cremonese, with Denzel Dumfries and Roberto Gagliardini stepping in behind Edin Dzeko and Lautaro Martinez.
It kicks off at the Stadio Giovanni Zini at 17.00 GMT.
The Nerazzurri went from joy to despair, as after crushing Milan 3-0 in the Supercoppa Italiana, they lost at home to Empoli and discovered Milan Skriniar won’t sign a new contract.
Skriniar is suspended today anyway, as he was sent off in that game, and joined on the naughty step by Nicolò Barella, with Marcelo Brozovic and Samir Handanovic injured.
Romelu Lukaku is left on the bench, as Dzeko is the on-form striker alongside Lautaro Martinez, while Francesco Acerbi steps into defence.
Cremonese are still looking for their first Serie A win of the season, but have turned a corner since Davide Ballardini took over, knocking Napoli out of the Coppa Italia and holding Bologna 1-1.
Charles Pickel sits out a ban with Luka Lochoshvili and Giacomo Quagliata injured.
There is a first start for January signing Marco Benassi, who arrived on loan from Fiorentina.
Cremonese: Carnesecchi; Vasquez, Chiriches, Bianchetti; Sernicola, Meité, Castagnetti, Benassi, Valeri; Ciofani, Okereke
Inter: Onana; Darmian, Acerbi, Bastoni; Dumfries, Gagliardini, Calhanoglu, Mkhitaryan, Dimarco; Dzeko, Lautaro Martinez