Milan try to get back on track in Serie A with Rafael Leao and Christian Pulisic, but Como pick Patrick Cutrone with Nico Paz only fit for the bench.
It kicks off at the Stadio Sinigaglia at 17.30 GMT.
This is a local derby, as Como and Milan are both in the Lombardy region and many of the players have homes near the lake.
Sergio Conceicao made the perfect debut by winning the Supercoppa Italiana in Riyadh, beating Juventus in the semi-final and then coming back from 2-0 down to defeat Inter.
Because of those fixtures, this Week 19 tie was rescheduled to this evening.
His Serie A bow was a disappointing 1-1 draw with Cagliari at San Siro, so much more is expected here.
Emerson Royal returns from suspension, with Ruben Loftus-Cheek, Samuel Chukwueze, Alessandro Florenzi and transfer-listed Noah Okafor out of action.
Ismael Bennacer comes in for Yunus Musah and his first Serie A start for five months, while Alvaro Morata plays despite being one yellow card away from missing this weekend’s clash with Juventus.
Como won two of their last three games, including a 2-0 against Roma, but Real Madrid academy product Nico Paz is only fit for the bench after an ankle sprain.
Instead, January signing Assane Diao gets his first start in support of former Milan striker Cutrone.
Maxence Caqueret is also available after his transfer from Olympique Lyonnais, but Sergi Roberto, Federico Barba, Daniele Baselli and Marco Sala miss out.
Como vs. Milan line-ups
Como: Butez; Goldaniga, Dossena, Kempf; Van Der Brempt, Engelhardt, Da Cunha, Fadera; Strefezza, Diao; Cutrone
Milan: Maignan; Emerson Royal, Thiaw, Tomori, Theo Hernandez; Bennacer, Fofana, Reijnders; Pulisic, Morata, Leao
Player statistic
| 20' |  |
Álvaro Morata | ||
| 33' | |
Ismaël Bennacer | ||
| 43' | |
Malick Thiaw |
| 53' | |
Álex Jiménez | ||
| 56' | |
Yunus Musah | ||
| Assane Diao (Assist: Maxence Caqueret) |
 |
60' | ||
| Marc Oliver Kempf | |
65' | ||
| 71' | |
Theo Hernández | ||
| 76' | |
Rafael Leão (Assist: Tammy Abraham) | ||
| 85' | |
Rafael Leão |
Match statistic
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