Victor Osimhen starts with Kvicha Kvaratskhelia and Giacomo Raspadori on the Serie A debut for new Napoli coach Francesco Calzona against Claudio Ranieri’s Cagliari.
It kicks off at the Unipol Domus Stadium in Sardinia at 14.00 GMT.
The Partenopei sacked Walter Mazzarri earlier this week and brought in Calzona, who is also keeping his other job as manager of the Slovakia national team.
He made his debut with a Champions League 1-1 draw against Barcelona on Wednesday, returning them to the 4-3-3 formation.
Giovanni Di Lorenzo is suspended, with Cyril Ngonge injured, but Osimhen has shaken off flu symptoms to start.
There are some surprises, as Piotr Zielinski returns and Giacomo Raspadori is picked ahead of Matteo Politano.
Cagliari are in penultimate place and stopped the run of four consecutive defeats with a 1-1 draw against Udinese.
Ibrahim Sulemana, Pantelis Hatzidiakos, Eldor Shomurodov and Marco Mancosu are out of action, but Gaetano Oristanio returns to the bench.
Cagliari: Scuffet; Nandez, Dossena, Mina, Augello; Deiola, Makoumbou; Jankto, Gaetano, Luvumbo; Lapadula
Napoli: Meret; Mazzocchi, Rrahmani, Juan Jesus, Olivera; Anguissa, Lobotka, Zielinski; Raspadori, Osimhen, Kvaratskhelia
Player statistic
| Gianluca Lapadula |  |
36' |
| Zito Luvumbo | |
48' | ||
| 65' |  |
Victor Osimhen (Assist: Giacomo Raspadori) | ||
| Nahitan Nández | |
68' | ||
| Alessandro Deiola | |
86' | ||
| Zito Luvumbo (Assist: Alberto Dossena) |
|
90+6' | ||
| 90+1' | |
Mathías Olivera |
Match statistic
