Leaders Milan miss Sandro Tonali, but Theo Hernandez returns for a trip to troubled Cagliari, with new Italy international Joao Pedro.
It kicks off at the Unipol Domus Sardegna Arena at 19.45 GMT.
The Rossoneri are top of the Serie A table, even though Inter have a game in hand, and are coming off back-to-back 1-0 victories.
Olivier Giroud has shaken off flu symptoms to start, but Tonali is still feeling unwell.
Daniel Maldini is left at home with injured Simon Kjaer and Tiemoue Bakayoko, though Theo Hernandez returns from suspension.
Cagliari remain in relegation danger after two consecutive defeats without finding the net.
Daniele Baselli has COVID-19, while Nahitan Nandez, Kevin Strootman and Sebastian Walukiewicz are injured.
Joao Pedro and Alessio Cragno has been called up for the Italy squad going into the World Cup play-off against North Macedonia.
Leonardo Pavoletti completes the attack, with former Milan youth product Raoul Bellanova on the wing.
Cagliari: Cragno; Goldaniga, Lovato, Altare; Bellanova, Marin, Grassi, Lykogiannis, Dalbert; Joao Pedro; Pavoletti
Milan: Maignan; Calabria, Kalulu, Tomori, Theo Hernandez; Bennacer, Kessie; Messias, Brahim Diaz, Leao; Giroud