Ciro Immobile leads the way with Sergej Milinkovic-Savic and Luis Alberto, but Cagliari have found their form with Joao Pedro and Gaston Pereiro.
It kicks off at the Sardegna Arena at 19.45 GMT.
Serie A Liveblog: Udinese-Sampdoria, Roma-Atalanta, Cagliari-Lazio
Maurizio Sarri’s Lazio need to get back on track after their last-gasp home defeat to Napoli, but Danilo Cataldi has joined Manuel Lazzari on the treatment table.
The good news is that Francesco Acerbi returns from the start in defence after a long lay-off.
Immobile is flanked by Felipe Anderson and Mattia Zaccagni, with Sergej Milinkovic-Savic and Luis Alberto in midfield.
Cagliari have turned a corner under Walter Mazzarri and clambered out of the relegation zone thanks to a five-round unbeaten run, including victories away to Atalanta and Torino, drawing with Fiorentina, Empoli and Napoli.
Nahitan Nandez, Kevin Strootman, Marko Rog and Sebastian Walukiewicz remain on the treatment table, with Daniele Baselli not fully fit either.
Joao Pedro is supported by Gaston Pereiro, while Alessio Cragno hopes to again perform heroics in goal.
Cagliari: Cragno; Goldaniga, Lovato, Altare; Bellanova, Marin, Grassi, Deiola, Dalbert; Pereiro, Joao Pedro
Lazio: Strakosha; Marusic, Luiz Felipe, Acerbi, Radu; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Immobile, Zaccagni