Juventus need to get back on track in Sardinia without Alvaro Morata, facing a desperate Cagliari side led by Joao Pedro.
It kicks off at the Unipol Domus Sardegna Arena at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Liveblog: Empoli-Spezia, Inter-Verona, Cagliari-Juventus
The Bianconeri are in the doldrums after losing at home to Inter, which ruled them out of the Scudetto race and even put a top four position in doubt.
Alvaro Morata and Mattia De Sciglio sit out bans, with Manuel Locatelli, Weston McKennie, Federico Chiesa, Kaio Jorge and Marley Ake injured.
Denis Zakaria and Arthur Melo return to the starting XI, with Luca Pellegrini back from suspension.
Paulo Dybala and Dusan Vlahovic lead the way upfront in a return to the 3-5-2 formation.
Cagliari risk relegation after four consecutive defeats and are getting increasingly desperate.
Edoardo Goldaniga sprained his ankle, joining Luca Ceppitelli, Nahitan Nandez and Kevin Strootman on the treatment table.
Alberto Grassi is suspended, but Leonardo Pavoletti and Razvan Marin are back after recovering from COVID-19.
Cagliari: Cragno; Altare, Lovato, Carboni; Bellanova, Deiola, Marin, Dalbert; Lykogiannis, Joao Pedro; Pavoletti
Cagliari bench: Aresti, Radunovic, Obert, Walukiewicz, Zappa, Baselli, Rog, Ceter, Keita Balde, Gaston Pereiro
Juventus: Szczesny; Danilo, De Ligt, Chiellini; Cuadrado, Zakaria, Arthur, Rabiot, Pellegrini; Dybala, Vlahovic
Juventus bench: Perin, Pinsoglio, Alex Sandro, Bonucci, Rugani, Bernardeschi, Miretti, Kean