The pressure is growing on Cagliari, as they are still without a single win this season, while newly-promoted Frosinone have a dismal away record.
It kicks off at the Unipol Domus Arena at 11.30 GMT.
Claudio Ranieri took his side to promotion last season via a dramatic play-off with Bari, but they have struggled so far, scraping just three draws from nine rounds and scoring five goals.
Simone Aresti, Elio Capradossi and Marko Rog are injured, while Zito Luvumbo leads the attack with support from Jakub Jankto and Marco Mancosu.
Frosinone were promoted top of the Serie B table and are comfortably in 12th place currently, albeit with a poor away record of two draws and as many defeats.
Luca Mazzitelli is suspended, with Abdou Harroui, Francesco Gelli and Sergio Kalaj injured.
Juventus-owned Enzo Barrenechea and Matias Soulé start with Real Madrid loaner Reinier, but Marvin Cuni is given the nod upfront.
Cagliari: Scuffet; Nandez, Goldaniga, Dossena, Augello; Makoumbou, Prati, Deiola; Jankto; Mancosu, Luvumbo
Frosinone: Turati; Lirola, Romagnoli, Monterisi, Marchizza; Brescianini, Barrenechea; Soulé, Reinier, Baez; Cuni.
Player statistic
| 23' |  |
Matìas Soulé (Assist: Reinier) | ||
| 25' |  |
Simone Romagnoli | ||
| Marco Mancosu |  |
30' | ||
| 37' | |
Matìas Soulé (Assist: Reinier) |
| 49' | |
Marco Brescianini (Assist: Pol Lirola) | ||
| Matteo Prati | |
58' | ||
| Gaetano Oristanio (Assist: Leonardo Pavoletti) |
|
72' | ||
| Antoine Makoumbou | |
76' | ||
| 85' | |
Mehdi Bourabia | ||
| 87' | |
Caleb Okoli | ||
| Leonardo Pavoletti (Assist: Nicolas Viola) |
|
90+4' | ||
| Leonardo Pavoletti (Assist: Alberto Dossena) |
|
90+6' | ||
| 90+5' | |
Riccardo Marchizza |
Match statistic
