Bologna must do without Riccardo Orsolini and pick Musa Barrow upfront, while Lazio are seeking a fourth straight Serie A victory even in the absence of Ciro Immobile.
It kicks off at the Stadio Dall’Ara at 19.45 GMT.
Both teams go into this fixture on generally good form, as Thiago Motta will receive the Serie A Coach of the Month award before kick-off.
That strong run was ended by a slender defeat to Torino, while the Biancocelesti have won three in a row in Serie A, but lost 2-1 at home to AZ Alkmaar in the Conference League Round of 16 on Tuesday.
Key players are out injured, Orsolini and Nico Dominguez for the hosts, Immobile and suspended Adam Marusic for the visitors.
Marko Arnautovic is yet again dropped in favour of Joshua Zirkzee and Barrow, while Felipe Anderson is the only real alternative as False 9 for Lazio.
Inevitably, Sinisa Mihajlovic will be remembered at the Stadio Dall’Ara, as Bologna was his final club as a coach and he was most closely bonded as a player with Lazio.
Bologna: Skorupski; Posch, Soumaoro, Lucumí, Cambiaso; Schouten, Moro; Aebischer, Ferguson, Kyriakopoulos; Barrow
Lazio: Provedel; Lazzari, Casale, Romagnoli, Hysaj; Milinkovic-Savic, Vecino, Luis Alberto; Pedro, Felipe Anderson, Zaccagni
Player statistic
| 23' |  |
Elseid Hysaj | ||
| Nikola Moro | |
24' | ||
| Lewis Ferguson | |
34' | ||
| 45+1' | |
Matías Vecino |
| 75' | |
Mattia Zaccagni |
Match statistic
