A victory here would make Inter the new Serie A leaders, but Bologna have Marko Arnautovic and Gary Medel back from suspension, while Samir Handanovic is struggling with a back injury.
It kicks off at the Stadio Dall’Ara at 19.15 UK time (18.15 GMT).
Serie A Liveblog: Bologna-Inter, Fiorentina-Udinese and Atalanta-Torino
These are all rescheduled Serie A Week 20 fixtures, called off on January 6 due to COVID-19 outbreaks.
A victory would put Inter top of the table, one point clear of Milan, so this could well be the decisive moment in the Scudetto race.
Robin Gosens, Arturo Vidal and Felipe Caicedo have not made the trip due to injury, while Handanovic was a major doubt until the last minute with a back problem.
The goalkeeper is not ready to play, so Ionut Radu gets his first Serie A appearance of the season, only his second overall after the Coppa Italia 3-2 win over Empoli in extra time on January 19.
The last time 24-year-old Romanian Radu played a Serie A match for Inter was a 3-1 win over Roma on May 12, 2021.
Lautaro Martinez is partnered by Joaquin Correa this time, while Federico Dimarco again fills in for Alessandro Bastoni.
Bologna welcome back Arnautovic, Medel and Adama Soumaoro from suspension, with Medel winning his appeal to have the two-match ban halved.
Mitchell Dijks is out of the squad, with Lukasz Skorupski, Jerdy Schouten and Emmanuel Vignato shaking off flu symptoms.
Coach Sinisa Mihajlovic, a former Inter player and assistant manager, is still watching from his hospital room while undergoing leukaemia treatment.
Bologna are unbeaten in four, including draws with Milan and Juventus.
Bologna: Skorupski; Soumaoro, Medel, Theate; De Silvestri, Svanberg, Schouten, Soriano, Hickey; Arnautovic, Barrow
Inter: Radu; Skriniar, De Vrij, Dimarco; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Lautaro, Correa
Ref: Doveri
Oh snap Radu is playing 😪
Knew it
I’m so enraged right now