The two form teams in Serie A face off, as Joshua Zirkzee and Alexis Saelemaekers’ Bologna take on Hakan Calhanoglu and Marcus Thuram’s runaway leaders Inter.
It kicks off at the Stadio Dall’Ara at 17.00 GMT.
Thiago Motta has made real contenders out of Bologna, who consolidated fourth place with a victory away to Atalanta last week.
That was their sixth consecutive Serie A win and made them genuine favourites for Champions League qualification.
Jesper Karlsson and Adama Soumaoro are injured, but Alexis Saelemaekers and Jens Odgaard both surprisingly start, leaving Dan Ndoye and Riccardo Orsolini on the bench.
This is a special moment for Giovanni Fabbian, who is at Bologna on loan from Inter,.
Inter have won all 12 competitive fixtures played in 2024 between Serie A, the Supercoppa Italiana and Champions League, where they will visit Atletico Madrid on Wednesday.
Alessandro Bastoni returns from suspension, so only Stefano Sensi and Juan Cuadrado are absent, as Hakan Calhanoglu, Davide Frattesi, Francesco Acerbi and Thuram are fit again.
Because the second leg of that Champions League Round of 16 is coming up, Lautaro Martinez is given a rare rest, creating a new partnership of Thuram and Alexis Sanchez.
This is a tricky test, as Bologna already upset Inter twice this season, drawing in Serie A and winning in extra time to eliminate them from the Coppa Italia.
Bologna: Skorupski; Posch, Beukema, Lucumi, Kristiansen; Aebischer, Freuler, Ferguson; Odgaard, Zirkzee, Saelemaekers
Inter: Sommer; Bisseck, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Carlos Augusto; Thuram, Alexis Sanchez
Player statistic
| Joshua Zirkzee |  |
25' | ||
| 37' |  |
Yann Bisseck (Assist: Alessandro Bastoni) |
| Remo Freuler | |
47' | ||
| 81' | |
Davy Klaassen |
Match statistic
