Atalanta welcome back Teun Koopmeiners with Rasmus Hojlund, Ademola Lookman and Jeremie Boga as they hope to continue their free-scoring form against Sampdoria.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 GMT.
Gian Piero Gasperini’s men have rediscovered their remarkable scoring touch, netting 16 goals in their last three games between Serie A and the Coppa Italia, including a 3-3 thriller with Juventus.
They are also preparing for a Coppa Italia quarter-final against Inter on Tuesday evening.
Jose Luis Palomino and Davide Zappacosta are injured, but Koopmeiners returns from suspension to bolster the midfield.
Duvan Zapata and Luis Muriel must take their spots on the bench, as the next generation of Boga, Lookman and Hojlund has taken over upfront.
Sampdoria have huge problems on and off the field, as Abdelhamid Sabiri and Omar Colley joined the extensive injury list with Ignacio Pussetto, Manuel De Luca and Andrea Conti.
The good news is that Manolo Gabbiadini has shaken off an injury and is ready to start against his old club, along with Sam Lammers, who is on loan from Atalanta.
Atalanta: Musso; Toloi, Scalvini, Djimsiti; Hateboer, De Roon, Koopmeiners, Maehle; Lookman, Hojlund, Boga
Sampdoria: Audero; Amione, Nuytinck, Murru; Leris, Rincon, Winks, Augello; Djuricic; Gabbiadini, Lammers