Walter Mazzarri looks to Giacomo Raspadori, Kvicha Kvaratskhelia and Matteo Politano for his Napoli ‘debut’ against Atalanta’s Charles De Ketelaere and Ademola Lookman.
It kicks off at the Gewiss Stadium at 17.00 GMT.
The Partenopei sacked coach Rudi Garcia after eight wins, four draws and four defeats between Serie A and the Champions League.
Mazzarri returns after a decade away from this club and returns the side to a 4-3-3 formation, the kind that won the Scudetto under Luciano Spalletti last season.
Victor Osimhen is only fit for the bench six weeks after a thigh injury on international duty, while Mario Rui and Jesper Lindstrom are out, plus Andre Frank Zambo Anguissa and Alex Meret not at 100 per cent.
Piotr Zielinski has recovered after leaving the Poland camp with tonsillitis.
Atalanta have Marten de Roon suspended, with Rafael Toloi, Jose Luis Palomino and El Bilal Toure injured, while Charles De Ketelaere makes his return from the start rather than Gianluca Scamacca.
CDK is supported by Lookman and Mario Pasalic, with Teun Koopmeiners dropping into midfield.
Giorgio Scalvini and Matteo Ruggeri have shaken off their fitness problems.
Atalanta: Carnesecchi; Scalvini, Djimsiti, Kolasinac; Zappacosta, Koopmeiners, Ederson, Bakker; Pasalic; De Ketelaere, Lookman
Napoli: Gollini; Di Lorenzo, Rrahmani, Natan, Olivera; Anguissa, Lobotka, Zielinski; Politano, Raspadori, Kvaratskhelia
Player statistic
| 21' |  |
Natan | ||
| Berat Djimsiti | |
27' | ||
| 44' |  |
Khvicha Kvaratskhelia (Assist: Giovanni Di Lorenzo) |
| Ademola Lookman (Assist: Hans Hateboer) |
|
53' | ||
| 60' | |
Giovanni Di Lorenzo | ||
| Sead Kolasinac | |
65' | ||
| 79' | |
Eljif Elmas (Assist: Victor Osimhen) |
Match statistic
